Your Address : Globalchemmade--Wuhu Nuowei Chemistry Technologies Co., Ltd.
Name:Wuhu Nuowei Chemistry Technologies Co., Ltd.
Type:Others
Tel:+86-0553-8233716
Fax:+86-0553-2911116
Email:1820824272@qq.com
Address:China(Mainland)
Products detail
| Product Name: | 5-I-Ara-2''-F-2''-dU |
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| CAS No: | 69123-98-4 | |
| Product Type: | Organic Chemicals and Derivatives -> Others | |
| Product spec: | 1 | |
| Packing: | According to the customer''s requirements | |
| Post Time: | 2019-07-23 | |
| Usage: | An antiviral agent; nucleoside analog with antihepatitis B activity | |
| Description: | Fialuridine (FIAU) is one of a series of 2''-fluoro-substituted arabinosyl pyrimidine nucleosides that have demonstrated potent antiviral activities against a number of clinically important viruses, including hepatitis B virus (HBV). Analogs of FIAU have been shown to inhibit viral replication in the woodchuck and duck models of HBV infection. Although the mechanism of the anti-HBV activity is not well understood, evidence suggests that the triphosphate analog of FIAU is a potent inhibitor of HBV DNA polymerase activity. During early clinical investigation FIAU showed much promise as an antiHBV drug because it markedly reduced the level of HBV DNA in the serum of patients with chronic hepatitis B. However, clinical trials were terminated after adverse events occurred following oral administration of FIAU (0.1 and 0.25 mg/kg of body weight per day) for more than 2 months. The mechanism of the unexpected delayed toxicity is unresolved. | |